Small molecules inhibit growth of human tumor cells
Researchers from the Cancer Institute at NYU Langone Medical Center have identified three novel small molecules that interrupt a crucial cellular communication pathway that regulates many aspects of...
View ArticleB vitamins in mother's diet reduce colorectal cancer risk in offspring
Mice born to mothers who are fed a diet supplemented with B vitamins are less likely to develop intestinal tumors, report scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging...
View ArticleAnimal model sheds light on rare genetic disorder, signaling pathway
A team of researchers from the University of Utah and Brigham Young University has developed a mouse model of focal dermal hypoplasia, a rare human birth defect that causes serious skin abnormalities...
View ArticleCleft lip corrected genetically in mouse model
Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research...
View ArticleBreast stem-cell research: Receptor teamwork is required and a new pathway...
Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary...
View ArticleWnt signaling pathway plays key role in adult nerve cell generation: study
Researchers from the University of Utah have gained new insight into the regulation of adult nerve cell generation in the hypothalamus, the part of the brain that regulates many aspects of behavior,...
View ArticleSoy-based compound may reduce tumor cell proliferation in colorectal cancer
Research on a soy-based treatment for colorectal cancer, a promising agent in ovarian cancer, and a new drug target for advanced prostate cancer was presented at the American Association for Cancer...
View ArticleFingernails reveal clues to limb regeneration
Mammals possess the remarkable ability to regenerate a lost fingertip, including the nail, nerves and even bone. In humans, an amputated fingertip can sprout back in as little as two months, a...
View ArticleScientists pinpoint proteins vital to long-term memory
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found a group of proteins essential to the formation of long-term memories.
View ArticleStem cells found to play restorative role when affecting brain signaling process
A study by a Korean team of neuroscientists has concluded that when mesenchymal stem cells (MSCs; multipotent structural stem cells capable of differentiation into a variety of cell types) are...
View ArticleFrom chick to bedside: Removing the Wnt barrier
Kick starting a process that might repair the damage done in cerebral palsy and multiple sclerosis could begin with disabling a driver that helps block regeneration, said Baylor College of Medicine...
View ArticleResearchers discover possible new target for sarcoma treatment and prevention
Researchers from Mount Sinai School of Medicine have discovered a protein signaling pathway that becomes hyperactivated in human sarcoma cells, suggesting that medications to inhibit this pathway may...
View ArticlePancreatic stem cells isolated from mice
Scientists have succeeded in growing stem cells that have the ability to develop into two different types of cells that make up a healthy pancreas. The research team led by Dr. Hans Clevers of the...
View ArticleResearchers reveal pathway that contributes to Alzheimer's disease
Researchers at Jacksonville's campus of Mayo Clinic have discovered a defect in a key cell-signaling pathway they say contributes to both overproduction of toxic protein in the brains of Alzheimer's...
View ArticleChemical probe to dissect role of potential cancer-causing proteins
Scientists have created a highly specific and well-characterised chemical probe which can switch off two important proteins implicated in cancer—shedding new light on the role these proteins play in...
View ArticleMyelin cells swing along blood vessels to traverse the brain
The cells that create myelin, a fatty material that insulates nerve fibers in the brain's white matter, migrate into the developing brain by climbing and swinging on blood vessels, according to new...
View ArticleWhat can Frizzled7 reveal about breast cancer development?
A new study shows that Frizzled7 (FZD7), a protein present on human breast epithelial cells and a component of the Wnt signaling pathway is uniquely controlled by the Notch signaling pathway, both of...
View ArticleStem cell study finds mechanism that controls skin and hair color
A pair of molecular signals controls skin and hair color in mice and humans—and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU...
View ArticleCOPD – what causes the lungs to lose their ability to heal?
In chronic obstructive pulmonary disease (COPD), the patients' lungs lose their ability to repair damages on their own. Scientists at the Helmholtz Zentrum München, partner in the German Center for...
View ArticleResearchers use stem cells to regenerate the external layer of a human heart
A process using human stem cells can generate the cells that cover the external surface of a human heart—epicardium cells—according to a multidisciplinary team of researchers.
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